SAMe 400 is s-adenosyl-L-methionine (SAMe), a key biological factor that drives a wide variety of essential biochemical reactions, including the methylation of DNA, catecholamine neurotransmitters (brain messenger-molecules), phospholipids, hormones, and chondrocytes (cartilage-forming cells). Research suggests SAMe's ability to support healthy mood function and to relieve symptoms and reduce functional impairment in osteoarthritis. SAMe 400 provides a full 400 mg of true SAMe ion per enterically coated tablet, with a minimum of 70% biologically active (S),S-diastereoisomer.

S-Adenosyl-l-methiononine, or SAMe, is a naturally-occurring physiological agent in the human body that forms an integral part of the methylation cycle. It is formed in the body through the combination of the amino acid methionine and adenosine triphosphate (ATP). This compound was first isolated in Italy in 1952 and is now a prescription drug in much of Europe, most commonly it seems, as an anti-depressant. Safe, energizing, and purported to treat depression twice as fast as standard anti-depressants such as Prozac, SAMe has become more popular than the latter in the nation of its discovery, in spite of being more expensive there. SAMe is also heavily studied for its ability to alleviate the conditions of osteoarthritis as well as to treat liver disease.